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Synonymous modification results in high-fidelity gene expression of repetitive protein and nucleotide sequences

Repetitive nucleotide or amino acid sequences are often engineered into probes and biosensors to achieve functional readouts and robust signal amplification. However, these repeated sequences are notoriously prone to aberrant deletion and degradation, impacting the ability to correctly detect and in...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Wu, Bin, Miskolci, Veronika, Sato, Hanae, Tutucci, Evelina, Kenworthy, Charles A., Donnelly, Sara K., Yoon, Young J., Cox, Dianne, Singer, Robert H., Hodgson, Louis
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403262/
https://ncbi.nlm.nih.gov/pubmed/25877922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.259358.115
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