Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines

To develop new anticancer drug candidates from 2-arylnaphthyridin-4-one (AN), we have designed and synthesized a series of 3′-hydroxy and 6-hydroxy derivatives of AN. The results of cytotoxicity screening indicated that the replacement of the 3′-methoxy moiety on the C-ring phenyl group of AN (6a–e)...

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Publicado no:Eur J Med Chem
Main Authors: Liu, Chin-Yu, Cheng, Yung-Yi, Chang, Ling-Chu, Huang, Li-Jiau, Chou, Li-Chen, Huang, Chi-Hung, Tsai, Meng-Tung, Liao, Chih-Chang, Hsu, Mei-Hua, Lin, Hui-Yi, Wu, Tian-Shung, Wen, Yen-Fang, Zhao, Yu, Kuo, Sheng-Chu, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403237/
https://ncbi.nlm.nih.gov/pubmed/25528332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.11.062
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