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Design and Synthesis of 2-(3-Benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one Analogs as Potent Antitumor Agents that Inhibit Tubulin Assembly

As part of our continuing investigation of azo-flavonoid derivatives as potential anticancer drug candidates, a series of 2-aryl-6,7-methylenedioxyquinolin-4-one analogs was designed and synthesized. The design combined structural features of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-...

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Hlavní autoři: Chang, Yu-Hsun, Hsu, Mei-Hua, Wang, Sheng-Hung, Huang, Li-Jiau, Qian, Keduo, Morris-Natschke, Susan L., Hamel, Ernest, Kuo, Sheng-Chu, Lee, Kuo-Hsiung
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761767/
https://ncbi.nlm.nih.gov/pubmed/19719238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900456w
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