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Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation
Hedgehog (Hh) signaling is essential for osteoblast differentiation in the endochondral skeleton during embryogenesis. However, the molecular mechanism underlying the osteoblastogenic role of Hh is not completely understood. Here, we report that Hh markedly induces the expression of insulin-like gro...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4403181/ https://ncbi.nlm.nih.gov/pubmed/25825734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502301112 |
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