α-Synuclein, a chemoattractant, directs microglial migration via H(2)O(2)-dependent Lyn phosphorylation

Malformed α-Synuclein (α-syn) aggregates in neurons are released into the extracellular space, activating microglia to induce chronic neuroinflammation that further enhances neuronal damage in α-synucleinopathies, such as Parkinson’s disease. The mechanisms by which α-syn aggregates activate and rec...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wang, Shijun, Chu, Chun-Hsien, Stewart, Tessandra, Ginghina, Carmen, Wang, Yifei, Nie, Hui, Guo, Mingri, Wilson, Belinda, Hong, Jau-Shyong, Zhang, Jing
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403145/
https://ncbi.nlm.nih.gov/pubmed/25825709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417883112
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