AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension

Endothelial cell dysfunction, characterized by a diminished response to endothelial cell–dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in endothelial-dependent vaso-dilation, a function mediated by local Ca(2+) influx through clusters of functionally coupled...

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Pubblicato in:Sci Signal
Autori principali: Sonkusare, Swapnil K., Dalsgaard, Thomas, Bonev, Adrian D., Hill-Eubanks, David C., Kotlikoff, Michael I., Scott, John D., Santana, Luis F., Nelson, Mark T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403000/
https://ncbi.nlm.nih.gov/pubmed/25005230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005052
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