Crystal structure of Hop2–Mnd1 and mechanistic insights into its role in meiotic recombination

In meiotic DNA recombination, the Hop2−Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism. Here, the crystal structure of Hop2−Mnd1 reveals that it forms a curved rod-like structure consisting of...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Kang, Hyun-Ah, Shin, Ho-Chul, Kalantzi, Alexandra-Styliani, Toseland, Christopher P., Kim, Hyun-Min, Gruber, Stephan, Peraro, Matteo Dal, Oh, Byung-Ha
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402518/
https://ncbi.nlm.nih.gov/pubmed/25740648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv172
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