Silencing IFN-γ binding/signaling in astrocytes vs. microglia leads to opposite effects on CNS autoimmunity

IFN-γ, the hallmark cytokine of Th1 cells, plays an important role in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Thus far, the role of IFN-γ in EAE has been largely studied through its effects on immune cells, while much less is known about its effec...

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Udgivet i:J Immunol
Main Authors: Ding, Xiaoli, Yan, Yaping, Li, Xing, Li, Ke, Ciric, Bogoljub, Yang, Jingxian, Zhang, Yuan, Wu, Shuai, Xu, Hui, Chen, Wanjun, Lovett-Racke, Amy E., Zhang, Guang-Xian, Rostami, Abdolmohamad
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402255/
https://ncbi.nlm.nih.gov/pubmed/25795755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303321
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