Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells

EA.hy 926 cells grown under low folate conditions adopt a “pro-atherosclerotic” morphology and biochemical phenotype. Pharmacologically relevant doses of the antifolate drug methotrexate (MTX) were applied to EA.hy 926 cells maintained in normal (Hi) and low (Lo) folate culture media. Under both fol...

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Bibliographic Details
Published in:Eur J Pharmacol
Main Authors: Summers, Carolyn M., Hammons, Andrea L., Arora, Jasbir, Zhang, Suhong, Jochems, Jeanine, Blair, Ian A., Whitehead, Alexander S.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402228/
https://ncbi.nlm.nih.gov/pubmed/24657277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2014.03.004
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