Pemetrexed alters folate phenotype and inflammatory profile in EA.hy 926 cells grown under low-folate conditions

Elevated homocysteine is a risk marker for several major human pathologies. Emerging evidence suggests that perturbations of folate/homocysteine metabolism can directly modify production of inflammatory mediators. Pemetrexed acts by inhibiting thymidylate synthetase (TYMS), dihydrofolate reductase (...

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Autors principals: Hammons, Andrea L., Summers, Carolyn M., Jochems, Jeanine, Arora, Jasbir S., Zhang, Suhong, Blair, Ian A., Whitehead, Alexander S.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051202/
https://ncbi.nlm.nih.gov/pubmed/22975265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2012.08.008
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