Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects

Human plasma butyrylcholinesterase (BChE) contributes to cocaine metabolism and has been considered for use in treating cocaine addiction and cocaine overdose. TV-1380 is a recombinant protein composed of the mature form of human serum albumin fused at its amino terminus to the carboxy-terminus of a...

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Detalles Bibliográficos
Publicado en:J Clin Pharmacol
Main Authors: Cohen-Barak, Orit, Wildeman, Jacqueline, van de Wetering, Jeroen, Hettinga, Judith, Schuilenga-Hut, Petra, Gross, Aviva, Clark, Shane, Bassan, Merav, Gilgun-Sherki, Yossi, Mendzelevski, Boaz, Spiegelstein, Ofer
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2015
Assuntos:
Pharmacokinetics/Pharmacodynamics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402032/
https://ncbi.nlm.nih.gov/pubmed/25524052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.450
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