Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects

Human plasma butyrylcholinesterase (BChE) contributes to cocaine metabolism and has been considered for use in treating cocaine addiction and cocaine overdose. TV-1380 is a recombinant protein composed of the mature form of human serum albumin fused at its amino terminus to the carboxy-terminus of a...

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Detalles Bibliográficos
Publicado en:J Clin Pharmacol
Autores principales: Cohen-Barak, Orit, Wildeman, Jacqueline, van de Wetering, Jeroen, Hettinga, Judith, Schuilenga-Hut, Petra, Gross, Aviva, Clark, Shane, Bassan, Merav, Gilgun-Sherki, Yossi, Mendzelevski, Boaz, Spiegelstein, Ofer
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2015
Materias:
Pharmacokinetics/Pharmacodynamics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402032/
https://ncbi.nlm.nih.gov/pubmed/25524052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.450
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