Central nervous system effects of the histamine‐3 receptor antagonist CEP‐26401, in comparison with modafinil and donepezil, after a single dose in a cross‐over study in healthy volunteers

AIMS: In previous studies, the histamine‐3 receptor antagonist CEP‐26401 had a subtle effect on spatial working memory, with the best effect seen at the lowest dose tested (20 μg), and a dose‐dependent disruption of sleep. In the current study, 3 low‐dose levels of CEP‐26401 were compared with modaf...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Baakman, Anne C., Zuiker, Rob, van Gerven, Joop M.A., Gross, Nicholas, Yang, Ronghua, Fetell, Michael, Gershon, Ari, Gilgun‐Sherki, Yossi, Hellriegel, Edward, Spiegelstein, Ofer
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475682/
https://ncbi.nlm.nih.gov/pubmed/30710391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13885
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