MAP2K1 (MEK1) mutations define a distinct subset of lung adenocarcinoma associated with smoking

BACKGROUND: Genetic alterations affecting the MAPK/ERK pathway are common in lung adenocarcinoma (LAD). Early steps of the signaling pathway are most often affected with EGFR, KRAS and BRAF mutations encompassing over 70% of all alterations. Somatic mutations in MEK1, located downstream of BRAF, are...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Arcila, Maria E., Drilon, Alexander, Sylvester, Brooke E., Lovly, Christine M., Borsu, Laetitia, Reva, Boris, Kris, Mark G., Solit, David B., Ladanyi, Marc
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401580/
https://ncbi.nlm.nih.gov/pubmed/25351745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2124
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia