MAP2K1 (MEK1) mutations define a distinct subset of lung adenocarcinoma associated with smoking

BACKGROUND: Genetic alterations affecting the MAPK/ERK pathway are common in lung adenocarcinoma (LAD). Early steps of the signaling pathway are most often affected with EGFR, KRAS and BRAF mutations encompassing over 70% of all alterations. Somatic mutations in MEK1, located downstream of BRAF, are...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Arcila, Maria E., Drilon, Alexander, Sylvester, Brooke E., Lovly, Christine M., Borsu, Laetitia, Reva, Boris, Kris, Mark G., Solit, David B., Ladanyi, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401580/
https://ncbi.nlm.nih.gov/pubmed/25351745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2124
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