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EGFR Exon 20 Insertion Mutations in Lung Adenocarcinomas: Prevalence, Molecular Heterogeneity, and Clinicopathologic Characteristics

In contrast to other primary EGFR mutations in lung adenocarcinomas, insertions in exon 20 of EGFR have been generally associated with resistance to EGFR tyrosine kinase inhibitors. Their molecular spectrum, clinicopathologic characteristics and prevalence are not well established. Tumors harboring...

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Detalhes bibliográficos
Main Authors: Arcila, Maria E, Nafa, Khedoudja, Chaft, Jamie E, Rekhtman, Natasha, Lau, Christopher, Reva, Boris A, Zakowski, Maureen F, Kris, Mark G, Ladanyi, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714231/
https://ncbi.nlm.nih.gov/pubmed/23371856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0620
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