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EGFR exon 20 insertions in advanced lung adenocarcinomas: clinical outcomes and response to erlotinib

BACKGROUND: EGFR exon 20 insertions (exon20ins) represent approximately 10% of EGFR-mutant lung adenocarcinomas and are associated with resistance to EGFR tyrosine kinase inhibitors (TKIs). Clinical outcomes compared to patients with sensitizing EGFR mutations are not well-established. METHODS: Pati...

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Dettagli Bibliografici
Pubblicato in:Cancer
Autori principali: Naidoo, J, Sima, CS, Rodriguez, K, Busby, N, Nafa, K, Ladanyi, M, Riely, GJ, Kris, MG, Arcila, ME, Yu, HA
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807634/
https://ncbi.nlm.nih.gov/pubmed/26096453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29493
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