A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant.

Clinical resistance to antiviral drugs requires that a virus evade drug therapy yet retain pathogenicity. Thymidine kinase (TK)-negative mutants of herpes simplex virus are resistant to the drug, acyclovir, but are attenuated for pathogenicity in animal models. However, numerous cases of clinical re...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Hwang, C B, Horsburgh, B, Pelosi, E, Roberts, S, Digard, P, Coen, D M
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1994
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44015/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8202508/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.12.5461
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