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De novo design of a transmembrane Zn(2+)-transporting four-helix bundle
The design of functional membrane proteins from first principles represents a grand challenge in chemistry and structural biology. Here, we report the design of a membrane-spanning, four-helical bundle that transports first-row transition metal ions Zn(2+) and Co(2+), but not Ca(2+), across membrane...
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| Veröffentlicht in: | Science |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4400864/ https://ncbi.nlm.nih.gov/pubmed/25525248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1261172 |
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