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Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage
Chaperone-mediated autophagy (CMA) is activate in response to cellular stressors to prevent cellular proteotoxicity through selective degradation of altered proteins in lysosomes. Reduced CMA activity contributes to the decrease in proteome quality in disease and aging. Here, we report that CMA is a...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4400843/ https://ncbi.nlm.nih.gov/pubmed/25880015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7823 |
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