The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential

Cancer stem cells (CSC) are responsible for cancer chemoresistance and metastasis formation. Here we report that Δ133p53β, a TP53 splice variant, enhanced cancer cell stemness in MCF-7 breast cancer cells, while its depletion reduced it. Δ133p53β stimulated the expression of the key pluripotency fac...

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Publicat a:Stem Cell Reports
Autors principals: Arsic, Nikola, Gadea, Gilles, Lagerqvist, E. Louise, Busson, Muriel, Cahuzac, Nathalie, Brock, Carsten, Hollande, Frederic, Gire, Veronique, Pannequin, Julie, Roux, Pierre
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2015
Matèries:
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400643/
https://ncbi.nlm.nih.gov/pubmed/25754205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.02.001
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