Identification of a Novel HIV-1 Inhibitor Targeting Vif-dependent Degradation of Human APOBEC3G Protein

APOBEC3G (A3G) is a cellular cytidine deaminase that restricts HIV-1 replication by inducing G-to-A hypermutation in viral DNA and by deamination-independent mechanisms. HIV-1 Vif binds to A3G, resulting in its degradation via the 26 S proteasome. Therefore, this interaction represents a potential t...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Pery, Erez, Sheehy, Ann, Nebane, N. Miranda, Brazier, Andrew Jay, Misra, Vikas, Rajendran, Kottampatty S., Buhrlage, Sara J., Mankowski, Marie K., Rasmussen, Lynn, White, E. Lucile, Ptak, Roger G., Gabuzda, Dana
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400358/
https://ncbi.nlm.nih.gov/pubmed/25724652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.626903
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker