Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

Epigenetic events that are essential drivers of lymphocyte transformation remain incompletely characterized. We used models of Epstein-Barr virus (EBV)–induced B-cell transformation to document the relevance of protein arginine methyltransferase 5 (PRMT5) to regulation of epigenetic-repressive marks...

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Vydáno v:Blood
Hlavní autoři: Alinari, Lapo, Mahasenan, Kiran V., Yan, Fengting, Karkhanis, Vrajesh, Chung, Ji-Hyun, Smith, Emily M., Quinion, Carl, Smith, Porsha L., Kim, Lisa, Patton, John T., Lapalombella, Rosa, Yu, Bo, Wu, Yun, Roy, Satavisha, De Leo, Alessandra, Pileri, Stefano, Agostinelli, Claudio, Ayers, Leona, Bradner, James E., Chen-Kiang, Selina, Elemento, Olivier, Motiwala, Tasneem, Majumder, Sarmila, Byrd, John C., Jacob, Samson, Sif, Said, Li, Chenglong, Baiocchi, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2015
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400290/
https://ncbi.nlm.nih.gov/pubmed/25742700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-619783
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