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Lhx4 Deficiency: Increased Cyclin-Dependent Kinase Inhibitor Expression and Pituitary Hypoplasia

Defects in the Lhx4, Lhx3, and Pitx2 genes can cause combined pituitary hormone deficiency and pituitary hypoplasia in both humans and mice. Not much is known about the mechanism underlying hypoplasia in these mutants beyond generally increased cell death and poorly maintained proliferation. We iden...

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Publicado en:Mol Endocrinol
Autores principales: Gergics, Peter, Brinkmeier, Michelle L., Camper, Sally A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399274/
https://ncbi.nlm.nih.gov/pubmed/25668206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1380
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