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Mechanisms Underlying Pituitary Hypoplasia and Failed Cell Specification in Lhx3 Deficient Mice
The LIM-homeodomain transcription factor, LHX3, is essential for pituitary development in mouse and man. Lhx3 engineered null mice have profound pituitary hypoplasia that we find is attributable to an increase in cell death early in pituitary development. Dying cells are localized to regions of TPIT...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768753/ https://ncbi.nlm.nih.gov/pubmed/18037398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.10.006 |
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