The efficacy of the cyclin-dependent kinase 4/6 inhibitor in endometrial cancer

BACKGROUND: PD-0332991, the selective cyclin-dependent kinase 4/6 inhibitor palbociclib, causes cell cycle arrest by inhibiting phosphorylation of retinoblastoma (Rb) protein. The aim of this study was to evaluate the therapeutic potential of PD-0332991 in endometrial cancer. METHODS AND FINDINGS: F...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Tanaka, Tomohito, Terai, Yoshito, Ashihara, Keisuke, Fujiwara, Satoe, Tanaka, Yoshimichi, Sasaki, Hiroshi, Tsunetoh, Satoshi, Ohmichi, Masahide
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417643/
https://ncbi.nlm.nih.gov/pubmed/28472136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177019
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