Induction of Caspase-11 by Aspartyl Proteinases of Candida albicans and Implication in Promoting Inflammatory Response

We recently demonstrated that the secreted aspartyl proteinases (Saps), Sap2 and Sap6, of Candida albicans have the potential to induce the canonical activation of the NLRP3 inflammasome, leading to the secretion of interleukin-1β (IL-1β) and IL-18 via caspase-1 activation. We also observed that the...

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Bibliografische gegevens
Gepubliceerd in:Infect Immun
Hoofdauteurs: Gabrielli, Elena, Pericolini, Eva, Luciano, Eugenio, Sabbatini, Samuele, Roselletti, Elena, Perito, Stefano, Kasper, Lydia, Hube, Bernhard, Vecchiarelli, Anna
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2015
Onderwerpen:
Host Response and Inflammation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399077/
https://ncbi.nlm.nih.gov/pubmed/25712931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02895-14
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