Induction of Caspase-11 by Aspartyl Proteinases of Candida albicans and Implication in Promoting Inflammatory Response

We recently demonstrated that the secreted aspartyl proteinases (Saps), Sap2 and Sap6, of Candida albicans have the potential to induce the canonical activation of the NLRP3 inflammasome, leading to the secretion of interleukin-1β (IL-1β) and IL-18 via caspase-1 activation. We also observed that the...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Gabrielli, Elena, Pericolini, Eva, Luciano, Eugenio, Sabbatini, Samuele, Roselletti, Elena, Perito, Stefano, Kasper, Lydia, Hube, Bernhard, Vecchiarelli, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399077/
https://ncbi.nlm.nih.gov/pubmed/25712931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02895-14
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