Induction of Caspase-11 by Aspartyl Proteinases of Candida albicans and Implication in Promoting Inflammatory Response

We recently demonstrated that the secreted aspartyl proteinases (Saps), Sap2 and Sap6, of Candida albicans have the potential to induce the canonical activation of the NLRP3 inflammasome, leading to the secretion of interleukin-1β (IL-1β) and IL-18 via caspase-1 activation. We also observed that the...

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Publicado en:Infect Immun
Autores principales: Gabrielli, Elena, Pericolini, Eva, Luciano, Eugenio, Sabbatini, Samuele, Roselletti, Elena, Perito, Stefano, Kasper, Lydia, Hube, Bernhard, Vecchiarelli, Anna
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Host Response and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399077/
https://ncbi.nlm.nih.gov/pubmed/25712931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02895-14
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