Induction of Caspase-11 by Aspartyl Proteinases of Candida albicans and Implication in Promoting Inflammatory Response

We recently demonstrated that the secreted aspartyl proteinases (Saps), Sap2 and Sap6, of Candida albicans have the potential to induce the canonical activation of the NLRP3 inflammasome, leading to the secretion of interleukin-1β (IL-1β) and IL-18 via caspase-1 activation. We also observed that the...

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Bibliografiset tiedot
Julkaisussa:Infect Immun
Päätekijät: Gabrielli, Elena, Pericolini, Eva, Luciano, Eugenio, Sabbatini, Samuele, Roselletti, Elena, Perito, Stefano, Kasper, Lydia, Hube, Bernhard, Vecchiarelli, Anna
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2015
Aiheet:
Host Response and Inflammation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399077/
https://ncbi.nlm.nih.gov/pubmed/25712931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02895-14
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