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Pharmacological Activation of Rap1 Antagonizes the Endothelial Barrier Disruption Induced by Exotoxins ExoS and ExoT of Pseudomonas aeruginosa

Most clinical strains of Pseudomonas aeruginosa, a leading agent of nosocomial infections, are multiresistant to antibiotherapy. Because of the paucity of new available antibiotics, the investigation of strategies aimed at limiting the action of its major virulence factors has gained much interest....

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Publicado en:Infect Immun
Autores principales: Bouillot, Stéphanie, Attrée, Ina, Huber, Philippe
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399046/
https://ncbi.nlm.nih.gov/pubmed/25690098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00010-15
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