CYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes

AIM: To observe the relationship between ethanol-induced oxidative damage in human primary cultured hepatocytes and cytochrome P450 2E1 (CYP2E1) activity, in order to address if inhibition of CYP2E1 could attenuate ethanol-induced cellular damage. METHODS: The dose-dependent (25-100 mmol/L) and time...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Liu, Lie-Gang, Yan, Hong, Yao, Ping, Zhang, Wen, Zou, Li-Jun, Song, Fang-Fang, Li, Ke, Sun, Xiu-Fa
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2005
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398703/
https://ncbi.nlm.nih.gov/pubmed/16052683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v11.i29.4530
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