Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver

Protein kinase B (PKB/Akt) plays important roles in the regulation of lipid homeostasis, and impairment of Akt activity has been demonstrated to be involved in the development of non-alcoholic fatty liver disease (NAFLD). Previous studies suggest that cytochrome P4502E1 (CYP2E1) plays causal roles i...

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Vydáno v:Redox Biol
Hlavní autoři: Zeng, Tao, Zhang, Cui-Li, Zhao, Ning, Guan, Min-Jie, Xiao, Mo, Yang, Rui, Zhao, Xiu-Lan, Yu, Li-Hua, Zhu, Zhen-Ping, Xie, Ke-Qin
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633250/
https://ncbi.nlm.nih.gov/pubmed/28987868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.09.018
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