MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1

Atherosclerosis, a hyperlipidemia-induced chronic inflammatory process of the arterial wall, develops preferentially at sites where disturbed laminar flow compromises endothelial cell (EC) function. Here we show that endothelial miR-126-5p maintains a proliferative reserve in ECs through suppression...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Schober, Andreas, Nazari-Jahantigh, Maliheh, Wei, Yuanyuan, Bidzhekov, Kiril, Gremse, Felix, Grommes, Jochen, Megens, Remco T A, Heyll, Kathrin, Noels, Heidi, Hristov, Michael, Wang, Shusheng, Kiessling, Fabian, Olson, Eric N, Weber, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398028/
https://ncbi.nlm.nih.gov/pubmed/24584117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3487
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