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Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4

MicroRNAs regulate the maladaptation of endothelial cells (ECs) to naturally occurring disturbed blood flow at arterial bifurcations resulting in arterial inflammation and atherosclerosis in response to hyperlipidemic stress. Here, we show that reduced endothelial expression of the RNAse Dicer, whic...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hartmann, Petra, Zhou, Zhe, Natarelli, Lucia, Wei, Yuanyuan, Nazari-Jahantigh, Maliheh, Zhu, Mengyu, Grommes, Jochen, Steffens, Sabine, Weber, Christian, Schober, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742841/
https://ncbi.nlm.nih.gov/pubmed/26837267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10521
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