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Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4

MicroRNAs regulate the maladaptation of endothelial cells (ECs) to naturally occurring disturbed blood flow at arterial bifurcations resulting in arterial inflammation and atherosclerosis in response to hyperlipidemic stress. Here, we show that reduced endothelial expression of the RNAse Dicer, whic...

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Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Hartmann, Petra, Zhou, Zhe, Natarelli, Lucia, Wei, Yuanyuan, Nazari-Jahantigh, Maliheh, Zhu, Mengyu, Grommes, Jochen, Steffens, Sabine, Weber, Christian, Schober, Andreas
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742841/
https://ncbi.nlm.nih.gov/pubmed/26837267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10521
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