A possible role for AMP-activated protein kinase activated by metformin and AICAR in human granulosa cells

BACKGROUND: Women with polycystic ovary syndrome (PCOS) are generally insulin- resistant and are consequently often treated with metformin. We investigated the effect of metformin and AICAR on the AMP-activated protein kinase (AMPK) pathway. METHODS: We evaluated the effects of 5-amino-imidazole-4-c...

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Bibliographic Details
Published in:Reprod Biol Endocrinol
Main Authors: Kai, Yufuko, Kawano, Yasushi, Yamamoto, Hanae, Narahara, Hisashi
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397678/
https://ncbi.nlm.nih.gov/pubmed/25889494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12958-015-0023-2
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