BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints

BMP signaling mediated by ACVR1 plays a critical role for development of multiple structures including the cardiovascular and skeletal systems. While deficient ACVR1 signaling impairs normal embryonic development, hyperactive ACVR1 function (R206H in humans and Q207D mutation in mice, ca-ACVR1) resu...

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Dettagli Bibliografici
Pubblicato in:Dev Biol
Autori principali: Agarwal, Shailesh, Loder, Shawn J., Brownley, Cameron, Eboda, Oluwatobi, Peterson, Jonathan, Hayano, Satoru, Wu, Bingrou, Zhao, Bin, Kaartinen, Vesa, Wong, Victor C., Mishina, Yuji, Levi, Benjamin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397658/
https://ncbi.nlm.nih.gov/pubmed/25722188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.02.011
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