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Non-Aggregating Tau Phosphorylation by Cyclin-Dependent Kinase 5 Contributes to Motor Neuron Degeneration in Spinal Muscular Atrophy

Mechanisms underlying motor neuron degeneration in spinal muscular atrophy (SMA), the leading inherited cause of infant mortality, remain largely unknown. Many studies have established the importance of hyperphosphorylation of the microtubule-associated protein tau in various neurodegenerative disor...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Miller, Nimrod, Feng, Zhihua, Edens, Brittany M., Yang, Ben, Shi, Han, Sze, Christie C., Hong, Benjamin Taige, Su, Susan C., Cantu, Jorge A., Topczewski, Jacek, Crawford, Thomas O., Ko, Chien-Ping, Sumner, Charlotte J., Ma, Long, Ma, Yong-Chao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397602/
https://ncbi.nlm.nih.gov/pubmed/25878277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3716-14.2015
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