CopywriteR: DNA copy number detection from off-target sequence data

Current methods for detection of copy number variants (CNV) and aberrations (CNA) from targeted sequencing data are based on the depth of coverage of captured exons. Accurate CNA determination is complicated by uneven genomic distribution and non-uniform capture efficiency of targeted exons. Here we...

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Vydáno v:Genome Biol
Hlavní autoři: Kuilman, Thomas, Velds, Arno, Kemper, Kristel, Ranzani, Marco, Bombardelli, Lorenzo, Hoogstraat, Marlous, Nevedomskaya, Ekaterina, Xu, Guotai, de Ruiter, Julian, Lolkema, Martijn P, Ylstra, Bauke, Jonkers, Jos, Rottenberg, Sven, Wessels, Lodewyk F, Adams, David J, Peeper, Daniel S, Krijgsman, Oscar
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396974/
https://ncbi.nlm.nih.gov/pubmed/25887352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0617-1
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