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Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells.

The decrease in estrogen levels that follows the onset of menopause results in rapid bone loss and osteoporosis. The major effect of estrogen deficiency on bone metabolism is an increase in the rate of bone resorption, but the precise mechanism by which this occurs remains unresolved. A recently dev...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Oursler, M J, Pederson, L, Fitzpatrick, L, Riggs, B L, Spelsberg, T
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43967/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8202473/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.12.5227
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