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Rescuing the BMPR2 signaling axis in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a lethal disorder characterized by pulmonary arterial remodeling, increased right ventricular systolic pressure (RVSP), vasoconstriction and inflammation. The heritable form of PAH (HPAH) is usually (>80%) caused by mutations in the bone morphogenic protei...
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| Veröffentlicht in: | Drug Discov Today |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4396626/ https://ncbi.nlm.nih.gov/pubmed/24794464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2014.04.015 |
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