The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

Metabolic adaptation is essential for cell survival during nutrient deprivation. We report that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation. Tumor cells exploit this pa...

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Publicado no:Cell
Main Authors: Leprivier, Gabriel, Remke, Marc, Rotblat, Barak, Dubuc, Adrian, Mateo, Abigail-Rachele F., Kool, Marcel, Agnihotri, Sameer, El-Naggar, Amal, Yu, Bin, Somasekharan, Syam Prakash, Faubert, Brandon, Bridon, Gaëlle, Tognon, Cristina E., Mathers, Joan, Thomas, Ryan, Li, Amy, Barokas, Adi, Kwok, Brian, Bowden, Mary, Smith, Stephanie, Wu, Xiaochong, Korshunov, Andrey, Hielscher, Thomas, Northcott, Paul A., Galpin, Jason D., Ahern, Christopher A., Wang, Ye, McCabe, Martin G., Collins, V. Peter, Jones, Russell G., Pollak, Michael, Delattre, Olivier, Gleave, Martin E., Jan, Eric, Pfister, Stefan M., Proud, Christopher G., Derry, W. Brent, Taylor, Michael D., Sorensen, Poul H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395874/
https://ncbi.nlm.nih.gov/pubmed/23706743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.04.055
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