High Capsid–Genome Correlation Facilitates Creation of AAV Libraries for Directed Evolution

Directed evolution of adeno-associated virus (AAV) through successive rounds of phenotypic selection is a powerful method to isolate variants with improved properties from large libraries of capsid mutants. Importantly, AAV libraries used for directed evolution are based on the “natural” AAV genome...

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Udgivet i:Mol Ther
Main Authors: Nonnenmacher, Mathieu, van Bakel, Harm, Hajjar, Roger J, Weber, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395795/
https://ncbi.nlm.nih.gov/pubmed/25586687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.3
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