Phosphatidylinositol-Glycan-Phospholipase D Is Involved in Neurodegeneration in Prion Disease

PrP(Sc) is formed from a normal glycosylphosphatidylinositol (GPI)-anchored prion protein (PrP(C)) by a posttranslational modification. Most GPI-anchored proteins have been shown to be cleaved by GPI phospholipases. Recently, GPI-phospholipase D (GPI-PLD) was shown to be a strictly specific enzyme f...

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Udgivet i:PLoS One
Main Authors: Jin, Jae-Kwang, Jang, Byungki, Jin, Hyoung Tae, Choi, Eun-Kyoung, Jung, Cha-Gyun, Akatsu, Hiroyasu, Kim, Jae-Il, Carp, Richard I., Kim, Yong-Sun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395093/
https://ncbi.nlm.nih.gov/pubmed/25867459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122120
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