Influence of Inflammation on Voriconazole Metabolism

Voriconazole pharmacokinetics shows a large inter- and intrapatient variability. Inflammation is associated with changes in the expression of CYP isoenzymes. Here, we evaluated the influence of inflammation, marked by C-reactive protein (CRP) levels in blood, on the metabolism of voriconazole. Obser...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Encalada Ventura, M. A., Span, L. F. R., van den Heuvel, E. R., Groothuis, G. M. M., Alffenaar, J.-W. C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394835/
https://ncbi.nlm.nih.gov/pubmed/25733507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04789-14
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