Antileishmanial Effect of 18β-Glycyrrhetinic Acid Is Mediated by Toll-Like Receptor-Dependent Canonical and Noncanonical p38 Activation

18β-Glycyrrhetinic acid (GRA), a natural immunomodulator, greatly reduced the parasite load in experimental visceral leishmaniasis through nitric oxide (NO) upregulation, proinflammatory cytokine expression, and NF-κB activation. For the GRA-mediated effect, the primary kinase responsible was found...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Gupta, Purnima, Das, Pijush K., Ukil, Anindita
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Biologic Response Modifiers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394830/
https://ncbi.nlm.nih.gov/pubmed/25691644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03997-14
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