Leishmania donovani inhibits macrophage apoptosis and pro-inflammatory response through AKT-mediated regulation of β-catenin and FOXO-1

In order to establish infection, intra-macrophage parasite Leishmania donovani needs to inhibit host defense parameters like inflammatory cytokine production and apoptosis. In the present study, we demonstrate that the parasite achieves both by exploiting a single host regulator AKT for modulating i...

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Dettagli Bibliografici
Pubblicato in:Cell Death Differ
Autori principali: Gupta, Purnima, Srivastav, Supriya, Saha, Shriya, Das, Pijush K, Ukil, Anindita
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071566/
https://ncbi.nlm.nih.gov/pubmed/27662364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.101
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