Decreasing pfmdr1 Copy Number Suggests that Plasmodium falciparum in Western Cambodia Is Regaining In Vitro Susceptibility to Mefloquine

Dihydroartemisinin-piperaquine is the current frontline artemisinin combination therapy (ACT) for Plasmodium falciparum malaria in Cambodia but is now failing in several western provinces. To investigate artesunate plus mefloquine (AS+MQ) as a replacement ACT, we measured the prevalence of multiple...

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發表在:Antimicrob Agents Chemother
Main Authors: Lim, Pharath, Dek, Dalin, Try, Vorleak, Sreng, Sokunthea, Suon, Seila, Fairhurst, Rick M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2015
主題:
Susceptibility
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394809/
https://ncbi.nlm.nih.gov/pubmed/25712365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05163-14
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