Combination of the R263K and M184I/V Resistance Substitutions against Dolutegravir and Lamivudine Decreases HIV Replicative Capacity

Lignende værker

• Dolutegravir Resistance Mutation R263K Cannot Coexist in Combination with Many Classical Integrase Inhibitor Resistance Substitutions
  af: Anstett, Kaitlin, et al.
  Udgivet: (2015)
• Dolutegravir-Selected HIV-1 Containing the N155H and R263K Resistance Substitutions Does Not Acquire Additional Compensatory Mutations under Drug Pressure That Lead to Higher-Level Resistance and Increased Replicative Capacity
  af: Anstett, Kaitlin, et al.
  Udgivet: (2015)
• The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration
  af: Mesplède, Thibault, et al.
  Udgivet: (2017)
• Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity
  af: Mesplède, Thibault, et al.
  Udgivet: (2014)
• Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir
  af: Quashie, Peter K., et al.
  Udgivet: (2012)