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Virtually Instantaneous, Room-temperature [(11)C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes

A new radiosynthetic protocol for the preparation of [(11)C]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L•Pd(Ar)X complexes (L=biaryl phosphine) with [(11)C]HCN. The strategy is operationally simple, exhibits a remarkably wide substrate scope wi...

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Bibliografski detalji
Izdano u:J Am Chem Soc
Glavni autori: Lee, Hong Geun, Milner, Phillip J., Placzek, Michael S., Buchwald, Stephen L., Hooker, Jacob M.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394387/
https://ncbi.nlm.nih.gov/pubmed/25565277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja512115s
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