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Structural Requirements for Bisphosphonate Binding on Hydroxyapatite: NMR Study of Bisphosphonate Partial Esters
[Image: see text] Eighteen different bisphosphonates, including four clinically used bisphosphonate acids and their phosphoesters, were studied to evaluate how the bisphosphonate structure affects binding to bone. Bisphosphonates with weak bone affinity, such as clodronate, could not bind to hydroxy...
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| Pubblicato in: | ACS Med Chem Lett |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2015
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394349/ https://ncbi.nlm.nih.gov/pubmed/25893039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5004603 |
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