Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells

Cancer stem cells (CSCs) with enhanced tumorigenicity and chemoresistance are believed to be responsible for treatment failure and tumor relapse in ovarian cancer patients. However, it is still unclear how CSCs survive DNA-damaging agent treatment. Here, we report an elevated expression of DNA polym...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Srivastava, Amit Kumar, Han, Chunhua, Zhao, Ran, Cui, Tiantian, Dai, Yuntao, Mao, Charlene, Zhao, Weiqiang, Zhang, Xiaoli, Yu, Jianhua, Wang, Qi-En
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394248/
https://ncbi.nlm.nih.gov/pubmed/25831546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421365112
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