Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells

Cancer stem cells (CSCs) with enhanced tumorigenicity and chemoresistance are believed to be responsible for treatment failure and tumor relapse in ovarian cancer patients. However, it is still unclear how CSCs survive DNA-damaging agent treatment. Here, we report an elevated expression of DNA polym...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Srivastava, Amit Kumar, Han, Chunhua, Zhao, Ran, Cui, Tiantian, Dai, Yuntao, Mao, Charlene, Zhao, Weiqiang, Zhang, Xiaoli, Yu, Jianhua, Wang, Qi-En
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394248/
https://ncbi.nlm.nih.gov/pubmed/25831546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421365112
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